Defining the role of lysosomal movement in age‐associated anabolic resistance in human skeletal muscle

We are currently recruiting participants for an exciting and novel research project in which we aim to understand why skeletal muscle of elderly individuals respond less to feeding and exercise compared to young individuals. This dampened response has been termed anabolic resistance and is believed to play a key role in the development of age-associated muscle loss (i.e. sarcopenia). Sarcopenia, which occurs independently of health status, leads to increased frailty, loss of mobility, an increased risk of falls and fractures and ultimately, a diminished quality of life.

By understanding why anabolic resistance occurs in elderly individuals, we hope that we will be able to develop interventions that can overcome this condition, thereby preventing the occurrence of sarcopenia. Thus, the overarching aim of this research is to improve the quality of life for a very large population of elderly individuals.

If you are eligible and willing to participate, you would be invited to four study visits. During these visits, you would perform resistance exercise and have your leg strength and body composition measured. During the last visit, you would also have muscle and blood samples taken to measure your specific response to feeding and exercise.

You may be eligible to participate if you are a healthy male aged between 65 and 75 years, have a BMI between 18 and 25 (check here:, are a non-smoker and of good general health.

For completing the study you would receive £200 remuneration for your time. In addition, you will get detailed information about your body composition and fitness level as well as access to the professional expertise of the research team on topics such as nutrition and exercise. Lastly, you will have the very rare benefit of knowing exactly how well you respond to exercise and food intake.

For more information, please contact DrWilliam Apro on or on 07572847201.

Read the full Participant Information Sheet – PIS v2 Lysotrack-ageing